POLY(HPMA-DICLOFENAC) CONJUGATE: SYNTHESIS, CHARACTERIZATION AND IN VITRO DRUG RELEASE STUDIES
作者: Neeraj Agrawal A Rohini M J N Chandrasekar I J Singhvi J Dwivedi P C Sharma K Gupta N Brar
刊名: Inventi Impact Med Chem, 2011, Vol.2011
来源数据库: Inventi
原始语种摘要: Diclofenac, a non-steroidal anti-inflammatory drug suffers from the side effects of upper GI damage (stomach and duodenum) including lesions ulcers and life threatening perforations and hemorrhage along with short biological half-life. A polymeric prodrug of diclofenac has been synthesized in the present work to overcome the limitations associated with the drug. The diclofenac was coupled to chloro derivative of hydroxy propyl methacrylate (HPMA) to get polymerisable monomeric drug conjugate which was in turn subjected to radicular polymerization to get the polymeric prodrug. The synthesized prodrug was characterized by IR, NMR and Mass spectroscopy. The prodrug was evaluated for its drug content and subjected for in vitro drug release studies in buffer solutions of pH 1.2 and 7.4...
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关键词翻译
关键词翻译
  • prodrug 药物前体
  • diclofenac 双氯芬酸
  • RELEASE 释放
  • radicular 胚根的
  • SYNTHESIS 综合
  • polymeric 聚合的
  • stomach 
  • release 释放
  • limitations 局限性
  • biological 生物学的