An overview of St14: A type II transmembrane serine protease
作者: Xiaoshuang Yan and Zhonghai Yan
刊名: Journal of Science and Applications: Biomedicine, 2015, Vol.3 (2)
来源数据库: International Union of Science and Education
关键词: St14HAIEmbryonic developmentCancer invasionMetastasis
原始语种摘要: St14 is a type II transmembrane serine protease that contains a cytoplasm N-terminal domain, a stem domain, and a serine protease catalytic domain. It is primarily synthesized as an inactive zymogen and co-expressed with the cognate inhibitor hepatocyte growth factor inhibitor (HAI) in epithelial cells. Accumulating evidence suggests that it plays critical roles in pre-implant embryonic compaction, placental development, as well as epidermal barrier formation after activation. The homologous ablation of St14 in mouse underlies the neonatal death at 48h for severe deficiency of the epidermal barrier. It has also been considered as a prognostic marker of epithelial cancers as it is involved in cancer metastasis and invasion in multiple ways by activating several kinds of substrates, such as...
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  • transmembrane 横跨膜的
  • protease 朊酶
  • homologous 同结构型的
  • inactive 不活泼的
  • domain 领域
  • several 各自
  • barrier 堡坝
  • inhibitor 抑制剂
  • expression 表示
  • hepatocyte 肝细胞