Elevation in Circulating Soluble CD40 Ligand Concentrations in Type 2 Diabetic Retinopathy and Association with its Severity
作者: Laila Ben LamineAmira TurkiGhada Al-KhateebNejla SellamiHagger B. AmorSameh SarrayMohamed JailaniMohamed GhorbelTouhami Mahjoub
刊名: Experimental and Clinical Endocrinology & Diabetes, 2018, pp.-
来源数据库: Thieme Journal
DOI: 10.1055/a-0647-6860
关键词: Diabetic retinopathyObesitySCD40LType 2 diabetes
英文摘要: Abstract Background To investigate the relationship between changes in circulating soluble CD40 ligand (sCD40L) levels and the presence and severity of type 2 diabetic retinopathy (DR). Subjects and methods sCD40L plasma concentrations were measured in 205 type 2 diabetes (T2DM) patients without DR (DWR; n=50) and with DR (n=155), the latter subdivided into non-proliferative diabetic retinopathy [NPDR; n=98 (63.2%)], or proliferative retinopathy [PDR; n=57 (36.8%)] patients. Results Receiver operating characteristic analysis provided good discriminatory power for sCD40L as predictor of DR presence, with high sensitivity and specificity. Categorizing DWR and DR patients into sCD40L quartiles, based on sCD40L concentrations in T2DM without DR, demonstrated statistically significant<span style="display: inline;">...</span><span class="summary_end" style="display: none;"> gradual increase in DR risk with increasing sCD40L levels. sCD40L levels were significantly higher in DR compared to DWR patients. Plasma sCD40L levels differed significantly according to DR severity, and correlated with diabetes duration, dyslipedimea, nephropathy, and presence of DR, but not with gender, age, SBP, DBP, FPG, HbA1c, T2DM medications. Linear regression analysis confirmed the association of increased sCD40L levels with DR, independent of others parameters; mean plasma sCD40L levels differing significantly according to DR severity. Conclusion Plasma sCD40L levels were positively associated with DR. The significant finding here is that sCD40L levels can be predictors of DR severity.</span> <div class="showall"> <a class="moreLink" onclick="MoreSummary(this);" style="display: normal;"><span class="caret"></span> 展开</a> <a class="moreLink" style="display: none;" onclick="ResetSummary(this);"><span class="caret-s-up"></span> 收缩</a> </div> </td> </tr> </tbody> </table> </div> <!--其他信息--> <div class="ZWJabtract-r"> <!--全文获取路径:全文链接,网络分享--> <script type="text/javascript"> function CoverimgError(defaultImg, event) { var e = window.event || event; var imgEle = e.target $(imgEle).attr("src", defaultImg); } </script> <span class="f14 strong">全文获取路径:</span> <a target="_blank" title="Thieme" class="downLink" href="/Link/DOI/WWMERGEJ03/SJGT0AD2F088AA8B685324206C18EEFBAE65"> <i class="downImg downCoper"></i>Thieme  <span class="f12"></span> </a> <div class="shareTo"> <span class="f14 strong">分享到:</span> <input type="hidden" id="detail_host" value="http://d.scholar.cnki.net" /> <input type="hidden" id="tablename" value="WWMERGEJ03" /> <input type="hidden" id="filename" value="SJGT0AD2F088AA8B685324206C18EEFBAE65" /> <input type="hidden" id="title" value="Elevation in Circulating Soluble CD40 Ligand Concentrations in Type 2 Diabetic Retinopathy and Association with its Severity" /> <a href="javascript:void(0);" onclick="ShareToSina();" title="新浪微博"> <i class="ishare ishare-weibo"></i> </a> <a href="javascript:void(0);" onclick="ShareToQQ();" title="QQ空间"> <i class="ishare ishare-qqzone"></i> </a> <a href="javascript:void(0);" onclick="ShareToKaixin();" title="人人"> <i class="ishare ishare-renren"></i> </a> <a href="javascript:void(0);" onclick="ShareToDouban();" title="豆瓣"> <i class="ishare ishare-douban"></i> </a> <a href="javascript:void(0);" onclick="ShareToEmail();" title="邮件"> <i class="ishare ishare-email"></i> </a> </div> <!--如果期刊信息存在--> <div class="LYCW"> <div class="f14 strong pb10">来源刊物:</div> <div class="CWImg"> <a href ="http://www.thieme.com/index.php?page=shop.product_details&amp;flypage=flypage.tpl&amp;product_id=970&amp;category_id=90&amp;option=com_virtuemart&amp;Itemid=53" title="Experimental and Clinical Endocrinology & Diabetes" target="_blank"> <img src="http://scholar.cnki.net/cover14/Cover/Thieme/c238d9ef7d9849dfac759d702dcd27d4.jpg" onerror="CoverimgError('http://scholar.cnki.net/cover14/Cover/noPic.jpg')" alt="期刊图片" /> </a> </div> <div class="CWDetail"> <div class="CWName"> <a href="http://www.thieme.com/index.php?page=shop.product_details&amp;flypage=flypage.tpl&amp;product_id=970&amp;category_id=90&amp;option=com_virtuemart&amp;Itemid=53" title="Experimental and Clinical Endocrinology & Diabetes" target="_blank">Experimental and Clinical Endocrinology & Diabetes</a></div> <div class="CWYin"><span class="gray">影响因子:</span><b>1.555</b> (2012) </div> </div> </div> <!--馆藏位置信息--> <div id="add_GCInfo"></div> <!--电商整合模块--> </div> </div> <input id="filename" type="hidden" value="SJGT0AD2F088AA8B685324206C18EEFBAE65" name="filename"/> <input class="articleType" type="hidden" value="journal"/> <input class="resourceTitle" type="hidden" value="Experimental and Clinical Endocrinology & Diabetes" /> <!--异步加载gif--> <div id="asynchLoading"></div> <!--参考、引证文献--> <div id="add_Reference"></div> <!--相似文献--> <div id="add_Similar" class="ZWJbody"></div> </div> <!--回到顶端按钮--> <div id="go2Top" class="divTop fixedBR"> <a class="totop" href="javascript:window.scrollTo(0,0);" title="返回顶部" onfocus="this.blur()"></a> </div> <div id="BackFrame"></div> <div id="FrontFrame"> <div id="FrontTitle"> <h2 class="Description"></h2> <a id="FrontClose" href="javascript:HideFrame()" title="关闭">×</a> </div> <iframe id="InnerFrame" src="about:blank" frameborder="0" scrolling="no"></iframe> </div> <div class="keywordsTrasBox"> <div class="kuewordsBtn"><a href="javascript:void(0);">关键词翻译</a></div> <div class="keywordsBox"> <a href="javascript:void(0);" class="delete" title="关闭"></a> <div class="keyTitle">关键词翻译</div> <div class="keylistBox"> <ul class="keylist"> <li><span>Association</span> <span class="bold">美国公共卫生协会</span></li> </ul> </div> </div> </div> <script type="text/javascript"> $(document).ready(function () { var translation = $.cookie("keyword_translation"); if (translation== "0") $(".keywordsBox").hide(); $(".kuewordsBtn").click(function () { $(".keywordsBox").fadeIn(); $.cookie("keyword_translation", "1", { expires: 7, path: '/' }); }); $(".keywordsBox a.delete").click(function () { $(".keywordsBox").fadeOut(); $.cookie("keyword_translation", "0", { expires: 7, path: '/' }); }); }); </script> <!--页尾--> <footer> <div class="footerL_gf-in"> <div class="bottom tc">资源合作:<a href="mailto:cnki.scholar@cnki.net">cnki.scholar@cnki.net</a>, +86-10-82896619  意见反馈: <a href="mailto:scholar@cnki.net">scholar@cnki.net</a></div> <div class="footerL_gf-n pl10 clearfix"> <ul class="footerL_nav f_img01"> <li class="nav-h pb10"><a href="http://elib.cnki.net/" target="_blank">CNKI数字图书馆</a></li> <li><a target="_blank" href="http://elib.cnki.net/">个人馆/机构馆</a></li> <li><a target="_blank" href="http://papers.cnki.net">学者成果库</a></li> <li><a target="_blank" href="http://xuezhe.cnki.net/">学者圈</a></li> <li><a target="_blank" href="http://projects.cnki.net/">科研项目</a></li> <li><a target="_blank" href="http://webinfo.cnki.net/">网络资源</a></li> <li><a target="_blank" href="http://trend.cnki.net/">CNKI学术趋势</a></li> </ul> <ul class="footerL_nav f_img02"> <li class="nav-h pb10"><a href="http://elearning.cnki.net/" target="_blank">数字化学习与研究</a></li> <li><a target="_blank" href="http://elearning.cnki.net/">数字化学习与研究平台<br>(CNKI E-Learning)</a></li> <li><a target="_blank" href="http://scholar.cnki.net">学术资源发现平台<br>(CNKI Scholar)</a></li> <li><a target="_blank" href="http://www.cnki.net/">中国知网</a></li> </ul> <ul class="footerL_nav f_img03 no_border"> <li class="nav-h pb10"><a target="_blank" href="http://service.cnki.net/">客户服务</a></li> <li><a target="_blank" href="http://my.cnki.net/CNKIRecharging/Pay.aspx">充值中心</a></li> <li><a target="_blank" href="http://help.cnki.net">在线咨询</a></li> <li><a target="_blank" href="http://service.cnki.net/">客服中心</a></li> <li><a target="_blank" href="http://scholar.cnki.net/help/help.aspx">帮助</a></li> </ul> <ul class="footerL_nav footerL_nav_logo f_img04 no_border"> <li class="nav-logo"><span class="logo_left"></span><a href="http://www.cnki.net/" target="_blank" class="logo_right"></a> <br> <a href="http://www.cnki.net/images/zhengshu02.jpg" target="_blank">京ICP证040431号</a>  <a href="http://www.cnki.net/images/006.jpg" target="_blank">互联网出版许可证 新出网证(京)字008号</a><br> 京公网安备:11010802014875号<br> © 2014中国知网(CNKI) 《中国学术期刊(光盘版)》电子杂志社有限公司 <div class="tongji"> <script type="text/javascript" src="http://s94.cnzz.com/stat.php?id=4113093&web_id=4113093&show=pic1"></script> </div> </li> </ul> </div> </div> </footer> <!-- 异步加载馆藏信息 --> <script type="text/javascript">referenceHelper.getGCInfo("SJGT0AD2F088AA8B685324206C18EEFBAE65", "")</script> <!--异步加载引文网络--> <script type="text/javascript">referenceHelper.getCitationRelation("SJGT0AD2F088AA8B685324206C18EEFBAE65")</script> <!--异步加载相似文献--> <script type="text/javascript">referenceHelper.getSimilar("美国公共卫生协会:9169,,Association:9169", "", "SJGT0AD2F088AA8B685324206C18EEFBAE65")</script> </body> </html>