Importance of Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis - A Retrospective Study of 4 Cases
作者: Sanaa HAMMIKhawla EL ATAOUNAKhalid BOUTIOumaima ELBOUAZZIMustapha LAINEJamal Eddine BOURKADI
作者单位: 1Pulmonology, Rabat.
刊名: International Journal of Medicine and Surgery, 2016, Vol.3 (1), pp.10-12
来源数据库: Mediterranean BioMedical Journals
DOI: 10.15342/ijms.v3i1.92
原始语种摘要: Background: In the treatment of active tuberculosis, therapeutic drug monitoring (TDM) is used to optimize dosing that maximizes therapeutic benefit while minimizing toxicity. In Morocco, TDM is not routinely used, yet low levels of anti-TB drugs can be associated with poorer treatment outcomes.Methods: We retrospectively checked our archives for patients with active TB for whom TDM was performed during 2014. Medical records were reviewed to abstract demographic, clinical, radiographic and microbiological data including time until smear and culture conversion. Then, we looked for cases with delay of TB conversion.Results: In total, 24 patients were identified, for whom TDM was performed, they all had low serum drug levels. Among them, 4 patients showed delayed bacteriological...
全文获取路径: 地中海生物医学期刊 

  • treatment 处理
  • follow 
  • TDM Time Division Modulation
  • Morocco 摩洛哥
  • therapeutic 治疗的
  • during 在的期间
  • radiographic 射线照相的
  • conversion 转换
  • dosage 放射剂量
  • their 他们的