Bryophyllum pinnatum leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells
作者: Kusworini HandonoTri W.I. DantaraElvira S. DewiMirza Z. PratamaNurdiana Nurdiana
作者单位: 1Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang
2Biomedical Sciences Master Program, Faculty of Medicine, Universitas Brawijaya, Malang
3Nursing Program, Faculty of Medicine, Universitas Brawijaya, Malang
4Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang
5Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang
刊名: Medical Journal of Indonesia, 2018, Vol.27 (4), pp.253-60
来源数据库: Medical Journal of Indonesia
DOI: 10.13181/mji.v26i4.1899
原始语种摘要: Background: B cells play a key role in systemic lupus erythematosus (SLE). Targeting B cells as SLE therapy is a plausible approach. This study investigated the potential effects of Bryophyllum pinnatum leaves with ethanol extract in decreasing percentages of maturation, increasing percentages of apoptosis, and decreasing NF-κB p65 expressions of SLE BALB/c mice B cells. Methods: Culturing B cells from pristane induced SLE BALB/c mice’s spleen will resulted in this in vitro study. B cells were activated by BAFF, LPS, IL-4, and anti-CD40 yielding CD19+ >80%. B cells were cultured by adding those stimulants with and without B. pinnatum leaves (0, 0.02, 0.1, or 0.5 µg/ml) for 72 hours at 37°C. Flow cytometry was performed to determine The Percentages of maturation (CD19+CD38+) and apoptosis...
全文获取路径: Medical Journal of Indonesia 
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关键词翻译
关键词翻译
  • lupus 豺狼座
  • cells 麻风细胞
  • maturation 成熟
  • systemic 系统的
  • ethanol 乙醇
  • SLE 全身性红斑狼疮
  • apoptosis 细胞死
  • extract 提取
  • promote 助长
  • percentage 百分数