Is tacrolimus more likely to induce diabetes mellitus than ciclosporin in heart transplant patients?
作者: Anisha Jagpal Sudeep Das De Sanjeet Singh Avtaar Singh Alan Kirk
刊名: Vessel Plus, 2018, Vol.2 (9)
来源数据库: OAE Publishing Inc.
DOI: 10.20517/2574-1209.2018.27
关键词: ImmunosuppressionHeart transplantationTacrolimusCiclosporinDiabetes
原始语种摘要: Aim: Immunosuppression has evolved since the first successful orthotopic heart transplant 50 years ago. Currently, calcineurin inhibitors lie at the focal point of the immunosuppressive regimen. However, these drugs exhibit a variety of side effects, including hyperglycaemia. This in turn compounds the risk of cardiovascular disease. There is conflict around which calcineurin inhibitor, tacrolimus or ciclosporin, is more likely to induce diabetes. Methods: A retrospective analysis of data from 52 patients who had received a heart transplantation at the Scottish heart transplant unit between January 2011 and August 2017. All patients received a combination immunosuppressive regimen consisting of mycophenolate mofetil, corticosteroids and either tacrolimus or ciclosporin. Fasting glucose...
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  • diabetes 糖尿病
  • tacrolimus 血流谱
  • transplant 移植体
  • heart 心脏
  • fasting 禁食
  • hyperglycaemia 高8糖
  • glucose 葡萄糖
  • regimen 生活制度
  • likely 大概
  • orthotopic 常位的