Heart and vascular remodeling in essential hypertension and type 2 diabetes is dependent on genetic polymorphisms
作者: Anna Shalimova
刊名: Vessel Plus, 2017, Vol.1 (2)
来源数据库: OAE Publishing Inc.
DOI: 10.20517/2574-1209.2016.08
关键词: Essential hypertensionType 2 diabetes comorbidityGenetic polymorphismHeart and vascular remodeling
原始语种摘要: Aim: To study heart and vascular remodeling in essential hypertension (EH) and concomitant type 2 diabetes mellitus (DM2) with respect to genetic polymorphism of the angiotensin II receptor type 1 (AGTR1) gene and peroxisome proliferator-activated receptor-γ2 (PPARγ2). Methods: Biochemical blood analysis, echocardiographic evaluation of mitral diastolic blood flow and tissue Doppler spectral modes, reactive hyperemia, color Doppler mapping. Results: Patients with A/C and C/C genotypes of the AGTR1 gene had higher blood pressure, more pronounced metabolic disorders, a larger left ventricle (LV), higher myocardial mass index left ventricle, and a greater intima media thickness (IMT), with a lower rate of endothelium-dependent vasodilation (EDVD) compared to the A/A genotype. Patients with...
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关键词翻译
关键词翻译
  • hypertension 高血压
  • vascular 维管的
  • diabetes 糖尿病
  • essential 本质的
  • remodeling 重新塑造
  • vasodilation 血管舒张
  • genetic 遗传的
  • angiotensin 血管紧张肽
  • polymorphism 多晶形
  • pronounced 明确的