Small dense and desialylated low density lipoprotein in diabetic patients
作者: Igor A. Sobenin Elena V. Galitsyna Andrey V. Grechko Alexander N. Orekhov
刊名: Vessel Plus, 2017, Vol.1 (1)
来源数据库: OAE Publishing Inc.
DOI: 10.20517/2574-1209.2016.12
关键词: Diabetes mellitusAtherosclerosisLow density lipoproteinDesialylated LDLSmall dense LDLElectronegative LDL
原始语种摘要: Aim: This study was undertaken to investigate the physicochemical properties of modified low density lipoprotein (LDL) in diabetes. Methods: LDL from 10 type 1 and 10 type 2 diabetic patients, as well as LDL from 10 non-diabetic subjects, was subdivided into bound and non-bound fractions by affinity chromatography on Ricinus communis agglutinin-agarose, and further characterized by sialic acid content, hydrated density, electrophoretic mobility, and the ability to induce cholesterol deposition in cultured cells. Results: The non-bound LDL fraction was similar to native LDL from healthy subjects, with respect to its physicochemical properties, and did not produce intracellular cholesterol accumulation. The bound LDL fraction was characterized by several alterations differentiating it from...
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  • 活动性 亲和力
  • lipoprotein 脂蛋白
  • density 密度
  • diabetic 糖尿病患者
  • cholesterol 胆甾醇
  • dense 致密的
  • bound 
  • diabetes 糖尿病
  • sialic 硅铝质的
  • affinity 亲和力
  • mobility 亲和力