Mitochondrial mutations associated with cardiac angina
作者: Margarita A. Sazonova Anastasia I. Ryzhkova Vasily V. Sinyov Marina D. Sazonova Nadezhda N. Nikitina Tatiana P. Shkurat Igor A. Sobenin Alexander N. Orekhov
刊名: Vessel Plus, 2019, Vol.3 (3)
来源数据库: OAE Publishing Inc.
DOI: 10.20517/2574-1209.2019.01
关键词: Cardiac anginaGeneMutationHeteroplasmy levelMitochondrial genomeMolecular cellular models
原始语种摘要: Aim: Cardiac angina is a disease in which discomfort or retrosternal pain may occur. Atherosclerosis of coronary arteries is one of the main risk factors for cardiac angina. The aim of the investigation was to analyze the association of 11 mitochondrial genome mutations with cardiac angina. In our preliminary studies an association of these mutations with atherosclerosis, a risk factor for cardiac angina, was found. Methods: We used samples of white blood cells collected from 192 patients with cardiac angina and 201 conventionally healthy study participants. DNA from blood leukocyte samples was isolated using a phenol-chloroform method. DNA amplicons containing the investigated regions of 11 mitochondrial genome mutations (m.12315G>A, m.652delG, m.5178C>A, m.14459G>A, m.3336T>C, 652insG,...
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关键词翻译
关键词翻译
  • 素质 基因组
  • angina 咽峡炎
  • cardiac 贲门
  • associated 相关的
  • discomfort 不舒适感
  • conventionally 按照惯例
  • found 创立
  • genome 基因组
  • predisposition 基因组
  • substitution 同位素置换
  • mutation 变种