To evaluate the clinical analgesic efficacy ofdexmedetomidine combined with sufentanil on uterinecontraction pain after transabdominal hysteromyomectomy. 60cases of patients applied with ASA I or II generalanesthesiain hysteromyomectomy, they are divided into two groupsaccording to randomized double-blind control (n=30): Group Sreceived 0.04ug/(kg•h) of sufentanil, Group Y received0.025ug/(kg•h) of sufentanil combined with 0.03ug/(kg•h) ofdexmedetomidine, both groups received compound use of 8mgOndansetron and 2.5mg Inapsine, which are diluted into 100mlwith normal saline, with background infusion at 2ml/h, PCAdose of 2ml and a 10min lockout interval. PCA pump wasimmediately connected after theoperation to record the BCScomfort scores, VAS scores, Ramsay sedation scores,effective pressing... number within 48h, dose of sufentanil,nausea and vomiting scores, MAP, HR, SPO 2% at 4h(T1),8h(T2), 16h(T3), 24h(T4) and 48h(T5) and satisfaction ofpatients within 48h. Compared with Group S, the VAS scoresof Group Y at 4h(T1), 8h(T2), 16h(T3), 24h(T4) and 48h(T5)were lower, self-controlled effective pressing number within48h declined, dose of sufentanil declined, and thepossibility of nausea and vomiting rate declined as well(P<0.05), while the comparison of both groups on Ramsaysedation scores at each time point after 48h of operationwas not statistically significant (P<0.05). The applicationof dexmedetomidine in PCIA after transabdominalhysteromyomectomy could decrease the dose of sufentanil,which could decrease the possibility of nausea and vomiting,obviously relieve the degree of uterine contraction pain, aswell as promote the degree of comfortand satisfaction ofpatients.