Article: Theexploration of modeling of rats with diabetic cardiomyopath
作者: LuyanYu YongjunMao
刊名: Chronic Diseases Prevention Review, 2018, Vol.2 (6), pp.16-21
来源数据库: Guoyu exquisite culture Co., Ltd
原始语种摘要: The complication of diabetic cardiomyopathy (DCM) is one ofthe major causes of death in diabetes mellitus (DM)patients. Accordingly, an effective animal model is playingan important role in investigating the pathogenesis of DCM.In this study, we randomized Sprague-Dawley (SD) rats into acontrol group and DCM group. The DCM rats were induced withintraperitoneal streptozotocin (STZ) injection. Eight weeksafter STZ injection, compared with the Control rats, the DCMrats exhibited a series of symptoms such as polydipsia,polyphagia, polyuria, weakness, hyperglycemia andemaciation. Echocardiography results revealed that the DCMrats had a left lower ventricular ejection fraction (LVEF),fractional shortening (FS) and E wave to A wave ratio (E/A)ratio than the Control rats. The results...
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  • diabetic 糖尿病患者
  • Article 物品
  • polyphagia 贪食
  • polyuria 多尿
  • streptozotocin 链脲佐菌素
  • hyperglycemia 高血糖
  • polydipsia 烦渴
  • cardiomyopathy 心肌病
  • diabetes 糖尿病
  • ejection 喷出