SYNTHESIS OF 3-AMINOMETHYLGLAUCINE DERIVATIVES AND IN VITRO EVALUATION OF THEIR ANTI-TYROSINASE, ANTIVIRAL AND RADICAL SCAVENGING ACTIVITIES
作者: Maya ChochkovaBoyka Stoykova Lubomira Nikolaeva-GlombStefan PhilipovTsenka Milkova
刊名: Journal of Chemical Technology and Metallurgy, 2020, Vol.55 (2)
来源数据库: University of Chemical Technology and Metallurgy
关键词: Glaucine3-aminomethylglaucineNa-protected amino acid amides of glaucineAntioxidant effectTyrosinase activityDPPH● test
原始语种摘要: A series of amides was synthesized by coupling of 3-aminomethylglaucine with various amino acid analogues. The reaction was carried out under mild conditions by using various carbodiimides and in the presence of catalytic amount of N-hydroxybenzotriazole. Five of the compounds obtained were new, and their spectral data are presented and discussed here. Selected amides were tested for their ability to scavenge the stable free 1,1-diphenyl-2-picrylhydrazyl (DPPH●) radical. The most active compounds were N-sinapoylphenylalanyl-3-aminomethylglaucine amide and N-feruloylphenylalanyl-3-aminomethylglaucine amide and their activity was due to the presence of hydroxycinnamoyl moiety in their molecules. The compounds were further tested in vitro for antiviral activity against viruses belonging to...
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关键词翻译
关键词翻译
  • amides 氨化物
  • amino 氨基
  • moiety 一部分
  • compounds 化合物
  • coupling 连接
  • catalytic 催化的
  • suggested 建议
  • activity 活度
  • Picornaviridae 小核粮核酸病毒
  • glaucine 海罂粟碱