Excessive use of fossil fuel results in a rapid depletion of non-renewable fossil energy resources, a rise in fuel cost and an uncontrolled emission of greenhouse gases, which causes a severe threat to the environment. This critical state has turned the awareness to explore renewable energy resources, which include water, biomass, wind and geothermal heat. Among these possibilities, biomass based fuels, i.e. biofuels, have been proposed as a substitute for conventional diesel and gasoline. The biofuels burn cleanly, thereby reducing harmful emissions, especially in the form of carbon monoxide, unburned hydrocarbon and toxic chemicals. This work aims at revealing the current state-of-the-art and the challenges in the application of integrated membrane bioreactors (MBRs) in biofuel... production. This innovative technology is employed for production of biofuels in gaseous and liquid state, such as biohydrogen, bio crude oil, bioethanol and biodiesel. Great opportunities for producing combustible gas mixtures open up broad prospects for integrated systems, and the low energy intensity makes them attractive for industrial developments. Coupling of bio processes and membrane filtration allows to solve the problem of producing methane and hydrogen without emission of carbon dioxide into the atmosphere. The main advantage of a MBR system is that it can be applied using environmentally friendly technology, i.e. biotechnology based on natural processes and mechanisms of conversion of substances by enzymes and microbial cultures. The waste and by-products of these processes can also serve as additional sources of raw materials, which leads to completely waste-free production.