Bradykinin restores left ventricular function, sarcomeric protein phosphorylation, and e/nNOS levels in dogs with Duchenne muscular dystrophy cardiomyopathy
作者: Jin Bo SuOlivier CazorlaStéphane BlotNicolas Blanchard-GuttonYounss Ait MouInès BarthélémyLucien SambinCarolina Carlos SampedranoVassiliki GouniYves UnterfingerPablo AguilarJean-Laurent ThibaudAlain BizéJean-Louis PouchelonHubert DabiréBijan GhalehAlain BerdeauxValérie ChetboulAlain LacampagneLuc Hittinger
刊名: Cardiovascular Research, 2012, Vol.95 (1), pp.86-96
来源数据库: Oxford University Press
DOI: 10.1093/cvr/cvs161
关键词: Duchenne muscular dystrophy cardiomyopathyMyofilament Ca2+ sensitivityProtein phosphorylationNitric oxide synthaseBradykinin
原始语种摘要: Aims Cardiomyopathy is a lethal result of Duchenne muscular dystrophy (DMD), but its characteristics remain elusive. The golden retriever muscular dystrophy (GRMD) dogs produce DMD pathology and mirror DMD patient's symptoms, including cardiomyopathy. We previously showed that bradykinin slows the development of pacing-induced heart failure. Therefore, the goals of this research were to characterize dystrophin-deficiency cardiomyopathy and to examine cardiac effects of bradykinin in GRMD dogs. Methods and results At baseline, adult GRMD dogs had reduced fractional shortening (28 ± 2 vs. 38 ± 2% in control dogs, P < 0.001) and left ventricular (LV) subendocardial dysfunction leading to impaired endo-epicardial gradient of radial systolic velocity (1.3 ± 0.1 vs. 3.8 ± 0.2 cm/s in control...
全文获取路径: Oxford U Press 
影响因子:5.94 (2012)

  • dystrophy 营养障碍
  • Duchenne dystrophy[医]杜兴肌营养不良
  • cardiomyopathy 心肌病
  • muscular 肌肉的
  • protein 蛋白质
  • subendocardial 心内膜下的
  • bradykinin 血管舒缓激肽
  • dystrophin 抗肌萎缩蛋白
  • DMD 需求
  • ventricular 室的