Introduction: The anatomic location of lesion in the brain influences the prognosis and treatment options. There is an increase in the incidence of primary lesions in brain in recent decades. The increasing incidence may be due to improved diagnostic methods such as modern radiologic imaging & better access to neurosurgical services. Objectives: The aim of this article is to study the incidence of brain tumors in two consecutive years. Methods: A total of 139 biopsies from brain and central nervous system were studied in patients attending NH Mallareddy Hospital, Suraram, Qutbullapur, Hyderabad, Telangana, India. The incidence of various lesions were studied lesion wise, location wise , age wise and sex wise. Results: In our study the most common lesion was glioma, commonly seen in third... and fourth decades and the common location being frontal lobe. Glioblastoma multiforme and other anaplastic variants were seen after 40 years and pilocytic astrocytoma was noted in children and young adults. Conclusion: The incidence of different gliomas were analyzed on the basis of anatomical location and its histological type. The area with densest occurrence was the anterior subcortical region in the frontal lobe. The most frequent subtypes were glioblastoma multiforme (31.8%), astrocytomas grade I , II and III (30.3%) and oligodendroglioma (13.6%). Our results demonstrate considerable heterogeneity in the anatomic distribution of gliomas in the brain.