Alteration of Local Microflora and α-defensins Hyper-production in Colonic Adenoma Mucosa
作者: Cristiano PagniniVito D. CorletoMaria Luisa MangoniEmanuela PilozziMaria Simona TorreRodolfo MarcheseAntonella CarnuccioEmilio Di GiulioGianfranco Delle Fave
刊名: Journal of Clinical Gastroenterology, 2011, Vol.45 (7), pp.602-610
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/MCG.0b013e31820abf29
原始语种摘要: BACKGROUND AND AIM: Gut flora/host interactions are fundamental for the maintenance of homeostasis. Evidence of possible regulatory effect of commensal bacteria on proliferative disorders of the colon is mounting. In this study, we explored the hypothesis that precancerous lesions, such as adenomas, present alteration of the local microflora and lead to an overproduction of antibacterial molecules of the innate immunity, namely α-defensins. Thus, the host-bacteria misbalance could represent a potential procarcinogenic factor. METHODS: Biopsies from adenomatous polyps and normal mucosa, in the rectum-sigmoid colon, were collected from 51 patients. Concentration of mucosal bacteria was evaluated by real-time polymerase chain reaction after extraction of total DNA. Total RNA was also...
全文获取路径: Wolters Kluwer 
影响因子:3.203 (2012)

  • overproduction 过度生产
  • evaluate 求...的值
  • relative 相对的
  • mucosa 粘膜
  • represent 代表
  • potential 
  • adenomatous 腺瘤的
  • increased 增加
  • alteration 蚀变
  • expression 表示