Cardioprotective Effects of an Active Metabolite of Furnidipine in 2 Models of Isolated Heart and on In Vivo Ischemia–induced and Reperfusion-induced Arrhythmias in Rats
作者: Tadeusz F KrzemińskiKatarzyna MitręgaBenoy VargheseDamian HudziakMaurycy PorcAgnieszka KędziaAndrzej W SielańczykAnna JabłeckaMarek Jasiński
作者单位: 1From the
刊名: Journal of Cardiovascular Pharmacology, 2011, Vol.57 (2), pp.183-193
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/FJC.0b013e318202e2ea
原始语种摘要: Dihydropyridines are known not only to have antiarrhythmic effects but also to exert a significant cardiac depressive influence. We previously showed that M-2, an active and final metabolite of furnidipine, had cardioprotective effects without the marked cardiac depression seen with this dihydropyridine. We studied the influence of M-2 infusion (10 M) on hemodynamics during low-flow and regional ischemia in the rat working heart. We examined the protection conferred by M-2 infusion (10 M) against effects of veratridine-induced intracellular calcium overload in the Langendorff heart. Additionally, we performed an in vivo study to explore the effects of oral administration of M-2 at different times and doses, in the ischemia- and reperfusion-induced arrhythmias model. M-2 improved coronary...
全文获取路径: Wolters Kluwer 
影响因子:2.383 (2012)

  • induced 感应的
  • pleiotropic 多向性的
  • metabolite 蚀变粗玻岩
  • against 反对
  • depressive 降低的
  • coronary 冠状的
  • administration 管理
  • ischemia 局部贫血
  • deleterious 有害的
  • infusion 浸剂