Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
作者: Wang-shu XuXuan SunCheng-guang SongXiao-peng MuWen-ping MaXing-hu ZhangChuan-sheng Zhao
作者单位: 1Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province; Neuroinfection and Neuroimmunology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing
2Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing
3Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang; Department of Neurology, Benxi Central Hospital of China Medical University, Benxi, Liaoning Province
4Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province
5Department of Medical Genetics, School of Basic Medicine, Peking University, Beijing
6Neuroinfection and Neuroimmunology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing
刊名: Neural Regeneration Research, 2016, Vol.11 (5), pp.745-751
来源数据库: Wolters Kluwer Journal
DOI: 10.4103/1673-5374.182700
原始语种摘要: Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia. We established a rat model of cerebral ischemia by injecting endothelin-1 in the left cortical motor area and left corpus striatum. Seven days later, bumetanide 200 µg/kg/day was injected into the lateral ventricle for 21 consecutive days with a mini-osmotic pump. Results demonstrated that the number of neuroblasts cells and the total length of dendrites increased, escape latency reduced, and the number of platform crossings increased in the rat hippocampal dentate gyrus in the chronic stage of cerebral ischemia. These findings suggest that...
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影响因子:0.144 (2012)

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关键词翻译
关键词翻译
  • dentate 锯齿状的
  • gyrus 脑回
  • bumetanide 布美他尼
  • ischemia 局部贫血
  • cerebral 大脑的
  • dendritic 师状的
  • chronic 延续很长的
  • precursor 前驱物质
  • development 开发
  • regeneration 再生