Design, Synthesis, Cytotoxicity and Molecular Docking Studies of Novel Baylis-Hillman Derived 1,2,3-Triazole Derivatives
作者: Amlipur SanthoshiShaik SadikhaRakthani BikshapathiChebolu Naga Sesha Sai Pavan KumarSree kanth Sivan
作者单位: 1Department of Chemistry, Hussainialam Degree College, Osmania University, Hyderabad-500007, Telangana, India
22 Division of Chemistry, Department of Sciences and Humanities, Vignan's Foundation for Science, Technology &Research, Vadlamudi, Guntur-522213, Andhra Pradesh, India
33 Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad-500 007, Telangana, India
44 Department of Chemistry, Nizam College [OU], Hyderabad-500001, Telangana, India
刊名: Der Pharma Chemica, 2018, Vol.10 (9), pp.97-104
来源数据库: Scholars Research Library
关键词: Baylis Hillman azides13-dipolar cycloaddition14-disubstituted 123-triazolesAnticancer activityDocking studies
原始语种摘要: A series of new 1,4-disubstituted 1,2,3-triazole derivatives are synthesized from Baylis-Hillman derived azides in a clean, efficient and simplemethod. These compounds are assessed for in vitro anticancer activity against six cancer cell lines and some of the compounds exhibited very good activity against different cell lines. Especially, three compounds 8h, 8i and 8j showed potent anticancer activity against prostateadenocarcinoma cancer cell line. Furthermore, molecular docking studies were carried out on DNA and eight different proteins involved in cancer progression to predict the possible molecular target for the synthesized molecule. As per docking results the molecules showed goodbinding values with respect to Heat Shock Protein and Epidermal Growth Factor Receptor, followed by...
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  • disubstituted 二基取代的
  • cycloaddition 环加
  • dipolar 双极
  • compounds 化合物
  • activity 活度
  • derivatives 派生物
  • anticancer 抗癌的
  • against 反对
  • docking 靠泊
  • triazole 三唑