Synthesis and Biological Evaluation of 2-Substituted Benzimidazole Derivatives
作者: Nilam B PawarDeepak YadavBhushan R Pawar
作者单位: 1Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satar, Survey No. 990, Maharashtra,India
刊名: Der Pharma Chemica, 2018, Vol.10 (9), pp.82-85
来源数据库: Scholars Research Library
关键词: Nonsteroidal Anti-inflammatoryAlbendazoleAnthelminticPheretima posthuma
原始语种摘要: A novel 2-substituted benzimidazole derivatives were synthesized by the reaction of naproxen with aromatic diamine-o-Phenylenediamine. All the compounds were characterized by InfraRed (IR), Proton Nuclear Magnetic Resonance (1H-NMR). The synthesized derivatives were screened for Anthelmintic and anti-inflammatory activities. Eicosanoids in Helminthes appear to play a dual role, for metabolism or maturation of the organism and communication with the host on a cellular basis. Production of eicosanoids correlates with both penetration and transformation, two activities required for infection. Eicosanoid is involved in control of virulence mechanisms. Therefore in the view of designing novel anthelmintic agent we have synthesized benzimidzole derivative of Naproxen. Naproxens react with free...
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关键词翻译
关键词翻译
  • amine 
  • anthelmintic 驱虫药
  • inflammatory 激怒的
  • derivatives 派生物
  • screened 筛过的
  • paralysis 麻痹
  • against 反对
  • benzimidazole 苯并咪唑
  • novel 长篇小说
  • naproxen 萘普生