Antimicrobial Evaluation of Some New Pyrazolyl Pyridinyl Coumarins
作者: Jigar MS
作者单位: 1SSR College of Arts, Commerce and Science, Sayli road, Silvassa, Dadra and Nagar Haveli-396230, India , India
刊名: Der Pharma Chemica, 2018, Vol.10 (8), pp.67-81
来源数据库: Scholars Research Library
关键词: CoumarinsPyridinylcoumarinsPyrazoleKr�hnke reactionAntimicrobial activity
原始语种摘要: The synthesis of various pyrazolyl pyridinyl substituted coumarins 3-{4'-[1''-phenyl -3''- (pyridin-3''' -yl)-1H- pyrazol- 4''-yl]- 6'-aryl -pyridin - 2'-yl} coumarins (4a-f) and 3-{4'-[1''-phenyl-3''-(pyridin-4'''-yl)-1H-pyrazol-4''-yl]-6'-aryl-pyridin-2'-yl}coumarins (5a-f) have been carried outby the reaction of 3-(3-(1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-4-yl)acryloyl)coumarins or 3-(3-(1-phenyl�3- (pyridin-4-yl)-1H�pyrazol-4-yl) acryloyl) coumarins with appropriate aroyl methyl pyridinium salts under Krohnke�s reaction condition. The synthesized compounds were fullycharacterized by Infrared (IR), Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 Nuclear Magnetic Resonance (13C-NMR), DEPT- 135, DEPT-90 and representative Mass spectral data. The synthesized...
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关键词翻译
关键词翻译
  • phenyl 苯基
  • acryloyl 丙烯酰基
  • reaction 反酌
  • NMR N-Modular Redundancy
  • pyrazolyl 吡唑基
  • pyridinium 吡啶盐
  • activity 活度
  • DEPT DEParTment
  • representative 代理的
  • antimicrobial 杀菌剂