Synthesis, Characterization and Antimicrobial Evaluation of Pyrimido Cyclohept[ B ] Indole Derivatives
作者: Ramya VSangeetha V
作者单位: 1Department of Chemistry, Kongunadu arts and Science College, Coimbatore, Tamil Nadu , India
刊名: Der Pharma Chemica, 2019, Vol.11 (3), pp.27-31
来源数据库: Scholars Research Library
关键词: PyrimidoMixed aldol condensationAntifungalAntibacterial
原始语种摘要: Some cyclohept[b]indole alkaloids were isolated from natural source and were mostly isolated from Ervatamia, Pandaca and Caulerpa that exhibit antimicrobial, anticancer, and anti-HIV activities. This work describes a strategic approach forthe synthesis ofefficient precursor 2-(4′-methyl)benzylidene-1-oxo-3,4,5,10-tetrahydrocyclohept[b]indole(3a)which can obtained by aldol condensation of the 7-methyl-1-oxo-2,3,4,5-tetra-hydrocyclohept[b]indole(1a) with 4-methyl benzaldehyde(2) under basic conditions. Hydroxypyrimido carbazoles were derived by the treatment of 2(4′-methyl)benzylidine-7-methyl-1-oxo-3,4,5,10-tetrahydrocyclohept[b]indole(3a) wastreatedwithurea and guanidine nitrate in sodium methoxide under proper condition.
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  • methyl 甲基
  • aldol 羟醛
  • condensation 冷凝
  • methoxide 甲醇盐
  • benzaldehyde 苯醛
  • benzylidene 苄叉
  • indole 吲哚
  • guanidine 
  • nitrate 硝酸盐
  • antimicrobial 杀菌剂