Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1
作者: Hongmei TangRui PanWenli FangYanyan XingDexi ChenXiaobao ChenYuanyuan YuJunbing WangZheng GongGuoyin XiongJun Dong
作者单位: 1Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University; Institute of Brain Research, Medical College of Jinan University; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hong Kong, Guangzhou 510632, Guangdong Province
2Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province
3Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province
4STD/AIDS Research Lab, Beijing Youan Hospital, Capital Medical University, Beijing 100069
刊名: Neural Regeneration Research, 2013, Vol.8 (15), pp.1368-1375
来源数据库: Wolters Kluwer Journal
DOI: 10.3969/j.issn.1673-5374.2013.15.003
关键词: neural regenerationtraditional Chinese medicinecurcumingp120 V3 loophuman immunodeficiency virus-1 associated neurocognitive disordersCa2+synapseapoptosisgrants-supported paperneuroregeneration
原始语种摘要: Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca2+ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine,...
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影响因子:0.144 (2012)

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关键词翻译
关键词翻译
  • curcumin 姜黄色素
  • induced 感应的
  • neuronal 二乙基溴乙酰胺
  • damage 损伤
  • human 人的
  • inhibiting 抑制
  • overload 超载
  • virus 病毒
  • effect 效应
  • intracellular 胞内的