Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy
作者: Manfred WiesslerUte HennrichRüdiger PipkornWaldemar WaldeckLiji CaoJörg PeterVolker EhemannWolfhard SemmlerTwan LammersKlaus Braun
刊名: Theranostics, 2011, Vol.1 , pp.381-394
来源数据库: Ivyspring Journal
原始语种摘要: Innovative and personalized therapeutic approaches result from the identification and control of individual aberrantly expressed genes at the transcriptional and post-transcriptional level. Therefore, it is of high interest to establish diagnostic, therapeutic and theranostic strategies at these levels. In the present study, we used the Diels-Alder Reaction with inverse electron demand (DARinv) click chemistry to prepare a series of cyclic RGD-BioShuttle constructs. These constructs carry the near-infrared (NIR) imaging agent Cy7 and the chemotherapeutic agent temozolomide (TMZ). We evaluated their uptake by and their efficacy against integrin αvβ3-expressing MCF7 human breast carcinoma cells. In addition, using a mouse phantom, we analyzed the suitability...
全文获取路径: Ivyspring 

  • targeted 对准目标的
  • observed 观察到的
  • constructs 建筑图纸生成系统
  • expressing 压榨
  • expressed 榨出的
  • imaging 图像形成
  • addition 添加
  • therapeutic 治疗的
  • quantitatively 定量的
  • mouse 小鼠