New Methods for Labeling RGD Peptides with Bromine-76
作者: Lixin LangWeihua LiHong-Mei JiaDe-Cai FangShushu ZhangXilin SunLei ZhuYing MaBaozhong ShenDale O. KiesewetterGang NiuXiaoyuan Chen
刊名: Theranostics, 2011, Vol.1 , pp.341-353
来源数据库: Ivyspring Journal
原始语种摘要: Direct bromination of the tyrosine residues of peptides and antibodies with bromine-76, to create probes for PET imaging, has been reported. For peptides that do not contain tyrosine residues, however, a prosthetic group is required to achieve labeling via conjugation to other functional groups such as terminal α-amines or lysine ε-amines. The goal of this study was to develop new strategies for labeling small peptides with Br-76 using either a direct labeling method or a prosthetic group, depending on the available functional group on the peptides. A new labeling agent, N-succinimidyl-3-[76Br]bromo-2,6-dimethoxybenzoate ([76Br]SBDMB) was prepared for cyclic RGD peptide labeling. N-succinimidyl-2, 6-dimethoxybenzoate was also used to pre-attach a 2,...
全文获取路径: Ivyspring 

  • conjugation 共轭
  • labeled 示踪的
  • functional 功能的
  • bromination 溴化
  • confirmed 已确认的
  • tyrosine 酪氨酸
  • either 任何
  • labeling 加标
  • available 可供应的