Multimodality Imaging of Tumor Response to Doxil
作者: Fan ZhangLei ZhuGang LiuNaoki HidaGuangming LuHenry S. EdenGang NiuXiaoyuan Chen
刊名: Theranostics, 2011, Vol.1 , pp.302-309
来源数据库: Ivyspring Journal
原始语种摘要: Purpose: Early assessment of tumor responses to chemotherapy could enhance treatment outcomes by ensuring that, from the beginning, treatments meet the individualized needs of patients. In this study, we applied multiple modality molecular imaging techniques to pre-clinical monitoring of early tumor responses to Doxil, focusing on imaging of apoptosis.;;Methods: Mice bearing UM-SCC-22B human head and neck squamous cancer tumors received either PBS or 1 to 2 doses of Doxil® (doxorubicin HCl liposome injection) (10 mg/kg/dose). Bioluminescence signals from an apoptosis-responsive reporter gene were captured for apoptosis evaluation. Tumor metabolism and proliferation were assessed by 18F-FDG and 3'-18F-fluoro-3'-deoxythymidine (18F-FLT) positron emission...
全文获取路径: Ivyspring 

  • imaging 图像形成
  • apoptosis 细胞死
  • fluoro 氟代
  • squamous 具鳞的
  • deoxythymidine 脱氧胸苷
  • pathological 病理学的
  • tumor 肿胀
  • positron 阳电子
  • metabolism 代谢
  • transferase 转移酵素