Induction of Apoptosis in Ehrlich Ascites Carcinoma Cells Through an Intrinsic Pathway by Ni(II)-benzoin Thiosemicarbazone Complex [Ni(BTSC)2]
作者: Mohammad Zakir HossainNazrul Islam Md.Hasan Sarkar MurshedKumar Dey AmitAmin RuhulKhanam JahanaraJesmin MeleParvin Nur HusnaM Mohsin Ali Shaikh
作者单位: 1Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh
2Department of Applied Chemistry and Chemical Engineering, University of Chittagong, Chittagong-4331, Bangladesh
3Bangladesh Council of Scientific and Industrial Research, Rajshahi, Bangladesh
4Department of Biochemistry & Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh
刊名: Journal of Cancer Research and Treatment, 2018, Vol.6 (2), pp.39-46
来源数据库: Science and Education Publishing
DOI: 10.12691/jcrt-6-2-3
原始语种摘要: Cancer is one of the leading causes of morbidity and mortality through worldwide. Globally cancer recognized as the second leading cause of death. Therefore, the discovery and development of new potent and selective anticancer drugs are of high importance in modern cancer research. The objective of this study was to find out the mechanism through which Ni(II)-benzoin thiosemicarbazone complex exerts its antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells bearing swiss albino mice. Induction of apoptosis in EAC cells was confirmed by observation of nuclear morphology and DNA fragmentation assay. The mRNA expression of several apoptotic genes like B-cell lymphoma 2 (bcl-2), B-cell lymphoma extra-large (bcl-xL) caspase-8, and proapoptotic genes p53 or tumor protein, bcl-2...
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  •  Interactive Interface
  • II Interactive Interface
  • Ni Interactive Interface
  • benzoin 苯偶姻
  • Induction 感应
  • lymphoma 淋巴瘤
  • mitochondria 线粒体
  • albino 白化体
  • confirmed 已确认的
  • protein 蛋白质
  • anticancer 抗癌的