Doxorubicin: Insights into Dynamics, Clinical Uses and Adverse Effects
作者: A. Alghorabi AmalM. Kabel AhmedA. Abd Elmaaboud Maaly
作者单位: 1Pharm D, College of Pharmacy, Taif University, Taif, Saudi Arabia
2Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
刊名: Journal of Cancer Research and Treatment, 2019, Vol.7 (1), pp.17-20
来源数据库: Science and Education Publishing
DOI: 10.12691/jcrt-7-1-3
原始语种摘要: Doxorubicin (DOX) is one of the anthracycline antibiotics that is used frequently for treatment of various types of malignancies including lung, breast and testicular cancers. DOX reacts with DNA by intercalation and inhibits the synthesis of DNA macromolecular components. Also, it may increase the production of free radicals which may contribute to its cytotoxicity. DOX may cause serious adverse effects including cardiotoxicity, hepatotoxicity and testicular toxicity. So, it has become increasingly important to find pharmacological remedies to protect against these serious adverse effects. This mini-review sheds light on DOX including its history, dynamics, clinical uses and adverse effects.
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关键词翻译
关键词翻译
  • toxicity 毒性
  • serious 认真的
  • including 包括(气导)包括……在内包括…在内
  • adverse 逆的
  • remedies 救济方法
  • contribute 贡献
  • protect 庇护
  • frequently 经常
  • macromolecular 大分子的
  • antibiotics 抗生物质