Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley
作者: Showket HussainNeha SinghIrfana SalamKapil BandilM YuvarajMohammad Akbar BhatMohammad Muzaffar MirMushtaq A. SiddiqiRanbir C SobtiMausumi BharadwajBhudev C. Das
作者单位: 11 Division of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, India
22 Department of Biotechnology, Panjab University, Chandigarh, India
33 Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
44 Department of Cardiovascular Thoracic Surgery, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
55 Department of Immunology and Molecular Medicine Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
66 Dr. B.R. Ambedkar Centre for Biomedical Research (ACBR) University of Delhi (North Campus), Delhi, India
刊名: Journal of Receptors and Signal Transduction, 2011, Vol.31 (2), pp.147-156
来源数据库: Informa Journal
DOI: 10.3109/10799893.2011.553836
原始语种摘要: Context : Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related deaths in Jammu and Kashmir. The negative regulation of tumor suppressor gene leading to change in signaling pathway is one of the major mechanisms responsible for tumorigenic transformation. Objective : In the present study, the role of silencing of suppressor of cytokine signaling-1 (SOCS-1) gene, a negative regulator of JAK/STAT pathway, was analyzed in ESCC. Methods : The expression pattern of SOCS-1 gene was analyzed in esophageal tumor biopsies although normal adjacent tissues that served as controls. Reverse transcriptase polymerase chain reaction (RT-PCR), immunohistochemistry, methylation-specific PCR (MSP), and human papillomavirus (HPV) detection were performed to assess the expression...
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关键词翻译
关键词翻译
  • esophageal 食管的
  • Kashmir 开士米
  • carcinoma 癌症
  • squamous 具鳞的
  • suppressor 抑制栅
  • silencing 消声
  • signaling 发信号
  • papillomavirus 乳头状瘤病毒
  • tumor 肿胀
  • methylation 甲基化酌