Nanohydroxyapatite (n-HA)/nylon6,6 composite scaffolds were produced by means of the salt-leaching/solvent casting technique. NaCl with distinct range size was used with the aim of optimizing the pores network; moreover, as synthesis composite powders with different n-HA content (40%, 60%) for scaffold fabrication were tested. The so-obtained composite scaffolds were characterized from a microstructural, mechanical and bioactivity point of view. The microstructure of the composite scaffolds possessed a well-developed interconnected porosity with optimal pore size ranging from 200 to 500 µm, ideal for bone regeneration and vascularization. The mechanical properties of the composite scaffolds were evaluated by compressive strength and modulus tests and results confirmed the similarity to... cortical bone. As regards the bioactivity, the composite scaffolds were immersed in simulated body fluid (SBF) in different periods and results was monitored by scanning electron microscopy (SEM) and energy dispersive X-ray microanalysis (EDX) in terms of forming apatite layer on scaffold surface.