Water scarcity presents the century’s biggest challenge for humankind. Most fresh water in the world (roughly two-thirds) is used for growing crops. Agriculture thus is the largest sink for freshwater in the world. So, the most important challenge in agriculture is irrigation, which consumes 70 percent of the world’s fresh water . Water scarcity directly translates in to food security. It is therefore required to adopt efficient technologies so as to improve the water use efficiency by making efficient utilization of water to produce more crop with minimum amount of water. Scientific irrigation scheduling can serve a lot in this regard to avoid the wastage of the precious water resource as well as to improve the productivity of the crops. In this context, a field investigation entitled... "Response of upland irrigated rice varieties to irrigations” was conducted at, Dr Panjabrao Deshmukh Krishi Vidyapeeth, Akola during the Kharif season of 2016-2017. The main plot treatments were: - Irrigation at 0.6, 0.8, 1.0 and 1.2 IW/CPE and subplot treatments consisted of four varieties: Avishkar, Parag, Sindewahi-1 and PBNR-03-02. The experimental results revealed that the rice varieties performed best at 1.2 IW/CPE, in which irrigation water was provided when cumulative pan evaporimeter reading reached 50 mm. The grain yield ,biological yield as well as water use efficiency was found to be the highest in irrigation at 1.2 IW/CPE and the variety Avishkar performed the best under the upland condition of the region in terms of yield as well as water use efficiency.