Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA
作者: Kontic M.Radovanovic S.Nikolic M.Bonaci-Nikolic B.
刊名: Medical Principles and Practice, 2012, Vol.21 (5), pp.488-491
来源数据库: Karger
DOI: 10.1159/000337944
关键词: Antineutrophil cytoplasmic autoantibodiesTuberculosisPropylthiouracilDrug-induced vasculitisBactericidal/permeability-increasing protein
原始语种摘要: Objective: To report the first case of concomitant drug- and infection-induced antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) in a patient treated with propylthiouracil (PTU) and suffering from tuberculosis. Presentation and Intervention: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase. Skin histopathology confirmed vasculitis. However, sputum examination revealed Mycobacterium tuberculosis . Remission was achieved after PTU withdrawal and treatment with antituberculosis drugs. Conclusion: Our case confirmed that BPI-ANCA are elevated in active tuberculosis. Multispecific ANCA were helpful for the...
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  • PTU Power Transfer Unit
  • tuberculosis 肺结核
  • proteinase 朊酶
  • confirmed 已确认的
  • elastase 弹性蛋白酶
  • vasculitis 血管炎
  • Mycobacterium -ria
  • histopathology 组织病理学
  • sputum 喀痰
  • induced 感应的