The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations
作者: Rodrigo F. OliveiraAnna TerrinGiulietta Di BenedettoRobert C. CannonWonryull KohMyungSook KimManuela ZaccoloKim T. Blackwell
作者单位: 11 The Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, United States of America
2 2 Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
3 3 Venetian Institute of Molecular Medicine, Padova, Veneto, Italy
4 4 Textensor Limited, Edinburgh, Scotland, United Kingdom
刊名: PLOS ONE, 2010, Vol.5 (7)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0011725
原始语种摘要: Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechanisms have been proposed to produce localized elevations in cAMP, known as microdomains: impeded diffusion, and high phosphodiesterase (PDE) activity. This paper investigates the mechanism of localized cAMP signaling using a computational model of the biochemical network in the HEK293 cell, which is a subset of pathways involved in PKA-dependent synaptic plasticity. This biochemical network includes cAMP production, PKA activation, and cAMP degradation by PDE activity. The model is implemented in...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • cAMP 环腺苷酸
  • PKA Public Key Algorithm
  • localized 修]定位[域
  • biochemical 生物化学的
  • concentration 浓度
  • required 必需
  • cytosol 细胞溶质
  • reaction 反酌
  • intracellular 胞内的
  • activity 活度