Three new C-27-carboxylated-lupane-triterpenoid derivatives from Potentilla discolor Bunge and their in vitro antitumor activities
作者: Jing ZhangChao LiuRi-Zhen HuangHui-Feng ChenZhi-Xin LiaoJin-Yue SunXue-Kui XiaFeng-Xiang Wang
作者单位: 11 Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, P. R. China
2 2 Institute of Agro-Food Science and Technology/Key Laboratory of Agro-Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences, Jinan, P. R. China
3 3 Biotechnology Center, Shandong Academy of Sciences, Jinan, P. R. China
4 4 Institute of Shandong River Wetlands, Laiwu, P. R. China
刊名: PLOS ONE, 2017, Vol.12 (4)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0175502
原始语种摘要: Three new lupane-triterpenoids ( 1 – 3 ) along with six known compounds ( 4 – 9 ) were isolated from the ethanolic extract of whole plant of Potentilla discolor Bunge. The structures of Compounds 1 – 3 were established by extensive 1D and 2D NMR together with other spectrum analysis, indicating that their C-27 positions were highly oxygenated, which were rarely found in nature. Their in vitro anti-proliferative activities against HepG-2, MCF-7 and T-84 cell lines were evaluated by Cell Counting Kit-8 (CCK-8) assay, and the results showed different activities for three cell lines with IC50 values ranging from 17.84 to 40.64 μM. In addition, the results from Hoechst 33258 and AO/EB staining as well as annexinV-FITC assays exhibited Compound 1 caused a markedly increased HepG-2...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • lupane 羽扇多环烷
  • triterpenoid 三萜系化合物
  • antitumor 抗癌的
  • developing 显影
  • discolor 变色
  • semisynthetic 半合成的
  • oxygenated 充氧的
  • mitochondria 线粒体
  • their 他们的
  • induced 感应的