Subcellular Location of PKA Controls Striatal Plasticity: Stochastic Simulations in Spiny Dendrites
作者: Rodrigo F. OliveiraMyungSook KimKim T. Blackwell
作者单位: 1The Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, United States of America
刊名: PLOS Computational Biology, 2012, Vol.8 (2)
来源数据库: PLOS
DOI: 10.1371/journal.pcbi.1002383
原始语种摘要: Dopamine release in the striatum has been implicated in various forms of reward dependent learning. Dopamine leads to production of cAMP and activation of protein kinase A (PKA), which are involved in striatal synaptic plasticity and learning. PKA and its protein targets are not diffusely located throughout the neuron, but are confined to various subcellular compartments by anchoring molecules such as A-Kinase Anchoring Proteins (AKAPs). Experiments have shown that blocking the interaction of PKA with AKAPs disrupts its subcellular location and prevents LTP in the hippocampus and striatum; however, these experiments have not revealed whether the critical function of anchoring is to locate PKA near the cAMP that activates it or near its targets, such as AMPA receptors located in the...
全文获取路径: PLOS 
影响因子:4.867 (2012)

  • PKA Public Key Algorithm
  • cAMP 环腺苷酸
  • dopamine 多巴胺
  • reward 报酬
  • adenylate 腙甙酸盐
  • cyclase 环化酶
  • protein 蛋白质
  • striatum 纹状体
  • striatal 纹状体的
  • inactivation 失活