No effect of norepinephrine dose on anti-Xa activity in critically ill patients
作者: Sjoerd D. MeenksNorbert A. FoudraineKelly BroenJos L.M.L. le NoblePaddy K.C. Janssen
刊名: Int. Journal of Clinical Pharmacology and Therapeutics, 2020, Vol.58 (4), pp.223-229
来源数据库: Dustri-Verlag Dr. Karl Feistle GmbH & Co. KG
DOI: 10.5414/CP203640
原始语种摘要: Objective: Low-molecular-weight heparins are frequently used to prevent venous thromboembolism. Vasopressor therapy may be associated with inadequate anti-factor Xa activity, thereby increasing the risk of venous thromboembolism. We aimed to assess the association between anti-factor Xa activity and norepinephrine dose in intensive care unit (ICU) patients treated with subcutaneous dalteparin for venous thromboembolism prophylaxis. Materials and methods: This was a prospective observational pilot study in adult ICU patients treated with dalteparin 5,000 IU subcutaneously once daily and norepinephrine > 0.25 µg/kg/min. Peak anti-factor Xa activity was monitored and dalteparin doses were adjusted following a predefined dose algorithm. Results: From November 2016 to April 2018, 32 patients...
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  • norepinephrine 正肾上腺素
  • activity 活度
  • critically 批判地
  • subcutaneous 皮下的
  • factor 因素
  • venous 多叶脉的
  • daily 每天的
  • effect 效应
  • following 追踪
  • observational 观察的