The Emerging Spectrum of Early Life Exposure-Related Inflammation and Epigenetic Therapy
作者: Qiwei Yang
刊名: Cancer Studies and Molecular Medicine - Open Journal, 2018, Vol.4 (1)
来源数据库: Openventio Publishers
DOI: 10.17140/CSMMOJ-4-125
关键词: Early life exposureEnvironmental factorsInflammationUterine fibroidsEpigenetic modifiers.
原始语种摘要: Early life exposure to a variety of insults during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life. During this process, inflammation triggered by a variety of adverse exposures plays an important role in the initiation and development of many types of diseases including tumorigenesis. This systematic review article summaries the current knowledge about the role and mechanism of inflammation in development of diseases. In addition, epigenome alteration related to inflammation and treatment options using epigenetic modifiers are highlighted and discussed.
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  • inflammation 炎症
  • exposure 暴露
  • epigenetic 后成的
  • development 开发
  • susceptibility 磁化率
  • reprogram 重编[可改编]程序
  • tumorigenesis 瘤形成
  • variety 变种
  • systematic 有系统的
  • triggered 触发的