Why HALO 301 Failed and Implications for Treatment of Pancreatic Cancer
作者: Muhammad W. Saif
刊名: Pancreas - Open Journal, 2019, Vol.3 (1)
来源数据库: Openventio Publishers
DOI: 10.17140/POJ-3-e010
关键词: Pegvorhyaluronidase alfa (PEGPH20)DesmoplasiaPancreatic cancerChemoresistanceHALO.
原始语种摘要: Survival rates for pancreatic cancer (PC) remain dismal. Current standard of care treatment regimens provide transient clinical benefit but eventually chemoresistance develops leading to poor outcomes. PC is a relatively chemoresistant tumor and one of the explanations for this is attributed to desmoplasia that impedes drug delivery. Based on this, stromal modifying agent such as Pegvorhyaluronidase alfa (PEGPH20) was developed and investigated in phase I-III studies. Although phase I-II studies showed promising results in patients with high hyaluronic acid (HA) expressing tumors, the phase III HALO 301 study failed to miss it’s primary endpoint and further development of PEHPH20 is halted. This failure implies that targeting desmoplasia alone is not sufficient and other intrinsic factors...
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关键词翻译
关键词翻译
  • desmoplasia 结缔组织生成
  • stroma 子座
  • restraining 抑制
  • pancreatic 胰的
  • targeting 导向目标
  • dismal 浅沼泽
  • Cancer 巨蟹座
  • characterize 成为...的特性
  • tumor 肿胀
  • physical 物理的