Developmental Exposure to Endocrine Disrupting Chemicals Alters the Epigenome: Identification of Reprogrammed Targets
作者: Qiwei Yang
刊名: Gynecology and Obstetrics Research – Open Journal, 2016, Vol.3 (1)
来源数据库: Openventio Publishers
DOI: 10.17140/GOROJ-3-127
关键词: Developmental environmental exposureEndocrine disrupting chemicalsEpigeneticsProstateFibroids.
原始语种摘要: Endocrine disruptions induced by environmental toxicants have placed an immense burden on society to properly diagnose, treat and attempt to alleviate symptoms and disease. Environmental exposures during critical periods of development can permanently reprogram normal physiological responses, thereby increasing susceptibility to disease later in life – a process known as developmental reprogramming. During development, organogenesis and tissue differentiation occur through a continuous series of tightly regulated and precisely-timed molecular, biochemical and cellular events. Humans may encounter Endocrine Disrupting Chemicals (EDCs) daily and during all stages of life, from conception and fetal development through adulthood and senescence. Though puberty and perimenopausal periods may be...
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  • development 开发
  • reprogramming 改编程序
  • expression 表示
  • proper 合适的
  • exposure 暴露
  • increased 增加
  • targeted 对准目标的
  • chromatin 染色质
  • organs 男生殖器
  • organogenesis 瀑形成