Roles of miR-128 in the pathogenesis of constipation and the related mechanism
作者: Cai He Tao Zhou* Li Liao
刊名: Advances in biology and medicine, 2019, Vol.4 (1)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: MiR-128ICCsConstipationProliferationApoptosis
原始语种摘要: Abstract The aim of this study is to explore the relationship between miR-128 and interstitial cells of Cajal (ICCs) in the pathogenesis of constipation and the related mechanism. We observed that the expression of miR-128 and c-kit were significantly down-regulated in constipated rats compared with the control rats; moreover, transient knockdown of miR-128 induced significant increase in the apoptosis and marked decrease in the proliferation of ICCs; finally, transfection of miR-128 inhibitors also lead to increased expression of Bax and Caspase-3, as well as reduced expression of Bcl-2 in ICCs. Taken together, our results proved for the first time that miR-128 can regulate the proliferation and apoptosis of ICCs via Bcl-2/Bax/Caspase-3 signaling pathway, suggesting that miR-128 has the...
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  • 此外 共同
  • constipation 粪结
  • related 有关的
  • mechanism 机构
  • expression 表示
  • knockdown 击倒
  • pathogenesis 发病机理
  • transfection 转染
  • regulate 控制
  • together 共同
  • moreover 共同