miR-768-3p serves as a negative regulator in the progression of gastric cancer by targeting eIF4E
作者: Shilong Shu* Faqiang Zhang Ke Lan
刊名: Advances in biology and medicine, 2018, Vol.3 (4)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: MiR-768-3pGastric cancerEIF4E
原始语种摘要: Abstract: Gastric cancer (GC) remains one of the most common malignancy globally, with high incidence and mortality rates. The dysregulation of miR-768-3p has been observed in several types of tumors, and it is involved in the carcinogenesis of GC. This present study aimed to determine the regulatory mechanisms of miR-768-3p in GC progression. First of all, we found that miR-768-3p expression was downregulated in human GC tissues and cell line MGC803. Furthermore, Ectopic expression of miR-768-3p mimics interfering RNA resulted in a decrease in cell proliferation and G1/S transition, as well as promotion of apoptosis. Further investigation in the present study indicated that the expression of eIF4E protein and mRNA were decreased following upregulation of the expression of miR-768-3p....
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  • targeting 导向目标
  • expression 表示
  • negative 负象
  • bioinformatics 生物信息学
  • interfering 干涉
  • demonstrated 探明的储量
  • observed 观察到的
  • several 各自
  • luciferase 荧光素酶