Resveratrol has effects to improve atherosclerosis in vivo study
作者: Lingli Zhu* Zonghua Guan Shiliang Zhang
刊名: Advances in biology and medicine, 2019, Vol.4 (1)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: Vascular calcificationAngiotensin II receptor 1 (AT1R)ResveratrolBMP2RUNX2
原始语种摘要: Abstract Aim: The aim of this study is to explain the effects and mechanism of resveratrol to improve atherosclerosis in vivo study. Methods: SD rats were divided randomly into control group, vascular calcification model group and treatment group. Vascular calcification models were made by subcutaneous injection of warfarin plus vitamin K1 for two weeks. Rats in the treatment group were subcutaneously injected with resveratrol ( 10 mg/kg) at the end of the first week and consecutively for two weeks.We observed the morphological changes by HE staining and the calcium deposition by Alizarin red staining in the artery vascular wall.The AT1R, RUNX2 and BMP2 proteins expressions were evaluated by WB assay. The apoptosis of smooth muscle cells (SMCs) were detected by TUNEL. Results: The aortic...
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  • resveratrol 白藜芦醇
  • calcification 钙化
  • vascular 维管的
  • subcutaneous 皮下的
  • treatment 处理
  • staining 染色
  • apoptosis 细胞死
  • improve 改进
  • effects 海员自身物品
  • receptor 接受体