The neuroprotective effects of Quercetin on hypoxic-ischemic brain injury in neonatal mice
作者: Yiwen Zhang* Yan Xiong Hongbo Pang
刊名: Advances in biology and medicine, 2018, Vol.3 (4)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: QuercetinHIEIKK-βNF-κB
原始语种摘要: Abstract: Aim: To investigate the effects of quercetin on hypoxic-ischemic injury (HI) in neonatal mice and the mechanisms of action. Methods: 40 male C57BL/6J neonatal mice aging seven days were randomly divided into 4 groups: a sham with normal saline group (SOS), a sham with Quercetin group (SOQ), a hypoxia/ischemia with normal saline group (IHS), and a hypoxia/ischemia with quercetin group (IHQ). Then, 72 h after HI, mice were sacrificed to collect the brain tissues. Measuring the IL-1α and IL-6 concentrations by Elisa assay in brain. The nerve cell apoptosis of mice brain were measured by TUNEL assay. The IKK-β and NF-κB proteins expressions were measured by Immunohistochemistry (IHC) assay. Area of infarction and cerebral damage were measured by Nissl staining. Results: HIE induced...
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  • neonatal 新生儿的
  • hypoxic 含氧量低的
  • brain 
  • ischemic 福尔克曼氏麻痹
  • depressed 扁平的
  • hypoxia 氧过少
  • infarction 梗塞
  • significantly 较大地
  • saline 盐的
  • suppressed 被抑制的