High expression of lncRNA FOXD2-AS1 promotes epithelial to mesenchymal transition of non-small cell lung cancer
作者: Yu Zhou* Yiping Wang Zhengxu Deng
刊名: Advances in biology and medicine, 2019, Vol.4 (1)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: FOXD2-AS1Epithelial-to-mesenchymal transitionNSCLC
原始语种摘要: Abstract Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer and the high mortality probably be caused by early invasion and metastasis. LncRNA FOXD2-AS1 is involved in tumor proliferation, invasion and metastasis. Epithelial-to-mesenchymal transition (EMT) is the main critical process of progression and metastasis. Therefore, the aim of the study is to investigate the expression of FOXD2-AS1 in NSCLC and identify the effects of FOXD2-AS1 on EMT in lung cancer. The results showed that the expression of FOXD2-AS1 was significantly upregulated in NSCLC, and over-expression of FOXD2-AS1 promoted cell migration and invasion in lung cancer cells. In addition, over-expression of FOXD2-AS1 regulated EMT-related molecules, for instance, the mRNA and protein expression...
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  • mesenchymal 间叶细胞的
  • expression 表示
  • transition 转移
  • cancer 癌症
  • metastasis 同质蜕变
  • invasion 侵入
  • EMT EMergency Treatment
  • protein 蛋白质
  • therapeutic 治疗的
  • epithelial 上皮的