Curcumin attenuates ovalbumin-induced asthma via regulating Th9 cell production
作者: Li Yang Wancheng Li Dan Yang Na Huang*
刊名: Advances in biology and medicine, 2018, Vol.3 (4)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: CurcuminAsthmaInterleukin 9T helper cell 9Tumor growth factor-β
原始语种摘要: Abstract: Curcumin is a polyphenol compound with anti-inflammatory effect. It can reduce the oxidative stress response of asthmatic patients by inhibiting the production of NO, thus alleviating the occurrence of airway inflammation. In this study, we further studied the molecular mechanism of curcumin in ovalbumin (OVA)-sensitized mice. Compared with OVA group, injection of curcumin reduced the number of inflammatory cells in bronchoalveolar lavage fluid (BALF) and attenuated airway sensitivity in mice. ELISA tests showed that curcumin reduced levels of tumor growth factor (TGF)-β, interleukin (IL)-4, IL-9, and IL-10 in BALF; IL-9 and IL-10 were also reduced in lung tissues. Western blot showed that curcumin inhibited collagen deposition and α-smooth muscle actin (α-SMA) secretion in lung...
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  • ovalbumin 卵白蛋白
  • asthma 哮喘
  • regulating 蝶的
  • curcumin 姜黄色素
  • induced 感应的
  • airway 航路
  • sensitized 敏化的
  • helper 助手
  • inhibiting 抑制
  • reduced 减缩的