Significance of lncRNA MALAT1 expression in peripheral blood in the short-term efficacy of radiotherapy for esophageal squamous cancer and its molecular mechanism
作者: Yunfei Gao Xi Lu Dongbo Luo Hongbo Lv Dan He Wei Sun*
刊名: Advances in biology and medicine, 2019, Vol.4 (1)
来源数据库: Hong Kong Heptaviolet Cultural Publishing Co., Limited
关键词: Esophageal squamous cancerMALAT1PrognosisRedioresistanceMiR-145
原始语种摘要: Abstract:Radiotherapy is the main treatment for many advanced esophageal squamous cell carcinoma (ESCC) patients. Recent studies demonstrated that patients with high level of long non-coding RNA (lncRNA) MALAT1 in tumor had poor prognosis. Thus, our study aims to investigate the significance of blood-derived MALAT1 in short-term efficacy of radiotherapy in ESCC and its underlying mechanism. LncRNA MALAT1 expression levels in plasma and serum from 47 ESCC patients were detected by quantitative RT-PCR. ESCC cell line EC9706 was transfected with siRNA to modulate MALAT1 expression. The effect of MALAT1 on cell growth, apoptosis, and radioresistance was studied in vitro. The results showed that there was a linear correlation between both plasma and serum MALAT1 level. MALAT1 level in plasma...
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  • squamous 具鳞的
  • esophageal 食管的
  • radiotherapy 放射线疗法
  • efficacy 效验
  • peripheral 周边的
  • expression 表示
  • mechanism 机构
  • cancer 癌症
  • prognosis 预报
  • serum 血清