Activated macrophages are crucial during acute PM2.5 exposure‑inducedangiogenesis in lung cancer
作者: Ruyi LiLiuqing YangNan JiangFeiyun WangPei ZhangRui ZhouJiange Zhang
作者单位: 1Department of Respiratory Medicine, The Second Xiangya Hospital,Central South University, Changsha, Hunan 410011, P.R. China
2Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai 201203,P.R. China
3Research Institute of Environmental Science, College of Chemistryand Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001,P.R. China
刊名: Oncology Letters, 2020, Vol.19 (1), pp.725-734
来源数据库: Spandidos Journal
DOI: 10.3892/ol.2019.11133
原始语种摘要: The importance of ambient particulate matter (PM2.5) in lung cancer progressionis well established; however, the precise mechanisms by which PM2.5 modulateslung cancer development have not yet been determined. The present study demonstratedincreased mRNA and protein expression levels of vascular endothelial growth factorin PM2.5‑induced macrophages. However, no significant changes to the expressionlevels of angiogenic cytokines (vascular endothelial growth factor A, matric metallopeptidase9, basic fibroblast growth factor and platelet‑derived growth factor) were observedin the Lewis lung carcinoma (LLC) cell line in response to acute PM2.5 exposure.PM2.5‑induced activated macrophages were revealed to upregulate angiogenic cytokineexpression following the acute exposure of LLC cells to...
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影响因子:0.237 (2012)

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关键词翻译
关键词翻译
  • macrophages 巨噬细胞
  • exposure 暴露
  • crucial 有决定性的
  • cancer 癌症
  • acute 急尖的
  • angiogenic 血管由来的
  • angiogenesis 血管生成
  • induced 感应的
  • findings 结论
  • growth 生长