Abnormal expression of miR‑135b‑5p in bone tissue of patients with osteoporosisand its role and mechanism in osteoporosis progression
作者: Biying ChenWen YangHuiqing ZhaoKaihua LiuAdi DengGuo ZhangKaixia Pan
作者单位: 1Department of Orthopaedics, The Third Affiliated Hospital ofSun Yat‑sen University, Guangzhou, Guangdong 510530, P.R. China
2Department of Rheumatology and Immunology, The Third AffiliatedHospital of Sun Yat‑sen University, Guangzhou, Guangdong 510530, P.R.China
刊名: Experimental and Therapeutic Medicine, 2020, Vol.19 (2), pp.1042-1050
来源数据库: Spandidos Journal
DOI: 10.3892/etm.2019.8278
原始语种摘要: Osteoporosis (OP) is an age‑related bone disease occurring worldwide. Osteoporoticfracture is one of the leading causes of disability and death in elderly patients.MicroRNAs (miRNAs/miRs) are key molecular regulatory factors in bone remodelingprocesses. The present study investigated the expression and mechanism of miR‑135b‑5pin patients with osteoporosis. The present results suggested that miR‑135b‑5pwas upregulated in bone tissue fragments of patients with osteoporosis comparedwith the control patients. MC3T3‑E1 cells were used to perform osteogenic differentiationinduction. Reverse transcription‑quantitative PCR and western blot assay wereused to detect the mRNA and protein expression levels of the osteogenic markersosteocalcin (OC), Osterix and alkaline phosphatase (ALP). A specific...
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  • osteoporosis 骨质疏松
  • expression 表示
  • ALP Airborne Line Printer
  • osteogenic 成骨的
  • mechanism 机构
  • induction 诱发
  • present 出席的
  • osteoblast 成骨细胞
  • reversed 倒转的
  • cells 麻风细胞