Construction and analysis of circular RNA molecular regulatory networksin clear cell renal cell carcinoma
作者: Chuanyu MaJie QinJunpeng ZhangXingli WangDongjun WuXiunan Li
作者单位: 1Department of Urology, The First Affiliated Hospital of DalianMedical University, Dalian, Liaoning 116600, P.R. China
刊名: Molecular Medicine Reports, 2020, Vol.21 (1), pp.141-150
来源数据库: Spandidos Journal
DOI: 10.3892/mmr.2019.10811
原始语种摘要: Increasing evidence has indicated that circular (circ)RNAs participate incarcinogenesis; however, the specific regulatory mechanisms underlying the effectsof circRNAs, microRNAs (miRNAs/miRs) and genes on the development of clear cellrenal cell carcinoma (CCRCC) remain unclear. In the present study, RNA microarraydata from CCRCC tissues and control samples were downloaded from the Gene ExpressionOmnibus and The Cancer Genome Atlas, in order to identify significantly dysregulatedcircRNAs, miRNAs and genes. The Cancer‑Specific circRNA Database was used to explorethe interactions between miRNAs and circRNAs, whereas TargetScan and miRDB wereemployed to predict the mRNA targets of miRNAs. Functional enrichment and prognosticanalyses were conducted in R. The results revealed that 324 circRNAs...
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  • Construction 建筑物
  • development 开发
  • regulatory 控制的
  • circular 循环的
  • including 包括(气导)包括……在内包括…在内
  • clear 昧的
  • analysis 分析
  • renal 肾的
  • carcinoma 癌症
  • process 过程