Increasing evidence has indicated that circular (circ)RNAs participate incarcinogenesis; however, the specific regulatory mechanisms underlying the effectsof circRNAs, microRNAs (miRNAs/miRs) and genes on the development of clear cellrenal cell carcinoma (CCRCC) remain unclear. In the present study, RNA microarraydata from CCRCC tissues and control samples were downloaded from the Gene ExpressionOmnibus and The Cancer Genome Atlas, in order to identify significantly dysregulatedcircRNAs, miRNAs and genes. The Cancer‑Specific circRNA Database was used to explorethe interactions between miRNAs and circRNAs, whereas TargetScan and miRDB wereemployed to predict the mRNA targets of miRNAs. Functional enrichment and prognosticanalyses were conducted in R. The results revealed that 324 circRNAs... were downregulated,whereas 218 circRNAs were upregulated in cancer. In addition, a circRNA‑miRNA‑mRNAinteraction network was constructed. Gene Ontology analysis of the upregulatedgenes revealed that these genes were enriched in biological processes, including‘flavonoid metabolic process’, ‘cellular glucuronidation’ and ‘T cell activation’.The downregulated genes were mainly enriched in biological processes, such as‘nephron development’, ‘kidney development’ and ‘renal system development’. Thehub genes, including membrane palmitoylated protein 7, aldehyde dehydrogenase6 family member A1, transcription factor AP‑2α, collagen type IV α 4 chain, nuclearreceptor subfamily 3 group C member 2, plasminogen, Holliday junction recognitionprotein, claudin 10, kinesin family member 18B and thyroid hormone receptor β,and the hub miRNAs, including miR‑21‑3p, miR‑155‑3p, miR‑144‑3p, miR‑142‑5p, miR‑875‑3p,miR‑885‑3p, miR‑3941, miR‑224‑3p, miR‑584‑3p and miR‑138‑1‑3p, were significantlyassociated with CCRCC survival. In conclusion, these results suggested that thesignificantly dysregulated circRNAs, miRNAs and genes identified in this studymay be considered potential biomarkers of the carcinogenesis of CCRCC and thesurvival of patients with this disease.