High PD‑L1 expression drives glycolysis via an Akt/mTOR/HIF‑1α axisin acute myeloid leukemia
作者: Ping MaMengtao XingLijie HanSilin GanJie MaFeifei WuYumin HuangYanli ChenWenliang TianChao AnHui SunLing Sun
作者单位: 1Department of Hematology, The First Affiliated Hospital of ZhengzhouUniversity, Zhengzhou, Henan 450052, P.R. China
2Department of Biological Sciences, University of Texas at ElPaso, El Paso, TX 79902, USA
刊名: Oncology Reports, 2020, Vol.43 (3), pp.999-1009
来源数据库: Spandidos Journal
DOI: 10.3892/or.2020.7477
原始语种摘要: Acute myeloid leukemia (AML) is a hematological malignancy derived fromimmature myeloid cells, which have the characteristics of abnormal proliferationand differentiation. Glycolysis has been a popular topic of research in recentyears, with increasing uptake and consumption of glucose. The present study aimedto investigate the glycolysis of tumor cells in patients with AML; in particular,how programmed cell death 1 ligand 1 (PD‑L1) regulates tumor cells glycolysisusing real time PCR (RT‑PCR), western blotting and flow cytometry. PD‑L1 highexpression predicted poor outcome in patients with AML in the public databaseGene Expression Profiling Interactive Analysis. PD‑L1 expression was decreasedin the samples from patients with AML with complete remission compared to thatin patients with...
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影响因子:2.297 (2012)

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关键词翻译
关键词翻译
  • myeloid 骨髓的
  • leukemia 白血病
  • glycolysis 糖解
  • AML Micro Switch
  • acute 急尖的
  • expression 表示
  • hematological 血液学的
  • remission 缓解
  • malignancy 恶性
  • cells 麻风细胞